An Oprah Winfrey Special

Main Cast

Episode Guide

Season 2024

• Episode 1: Shame, Blame and the Weight Loss Revolution
  Aired: Mar 18, 2024

  Oprah Winfrey hosts a sit-down conversation around the radical impact of prescription weight loss medications in the primetime event, "An Oprah Special: Shame, Blame and the Weight Loss Revolution," The special delves into the prevailing questions and concerns surrounding the impact on our health care, economy, lifestyle and culture. Speaking in front of a live studio audience, Oprah gathers the country's leading medical experts and everyday people who are in the battle of one of the biggest health care crises the world has ever known. For the first time in history, new drugs could prove to be the game changer to stem the tide of people living with obesity, an epidemic which has grown exponentially since the 1970s, costing $173 billion per year in medical costs in the United States alone.

• Episode 2: AI and the Future of Us
  Aired: Sep 12, 2024

  Exploring the profound impact of artificial intelligence on people's daily lives, demystifying the technology and empowering viewers to understand and navigate the rapidly evolving AI future.

Season 2025

• Episode 1: The Menopause Revolution
  Aired: Mar 31, 2025

  As women strive to understand and openly discuss the changes that impact every cell of their bodies, and new research shows women as young as 35 starting to show symptoms of perimenopause, Winfrey brings together a panel of renowned medical experts and leading voices to discuss the traditionally taboo topic of menopause before a live studio audience. Featured will be a group of women from all walks of life who have experienced a wide array of midlife transitions, as well as experts who explore the physical and neurological changes that occur during this life stage — a change that impacts every woman.